1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)-
BIBF0775
CAS: 334951-90-5
Molecular Formula: C31H34N4O2
1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- - Names and Identifiers
1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- - Physico-chemical Properties
| Molecular Formula | C31H34N4O2 |
| Molar Mass | 494.63 |
| Density | 1.223±0.06 g/cm3(Predicted) |
| Boling Point | 705.9±60.0 °C(Predicted) |
| Solubility | DMSO: 60 mg/mL( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| pKa | 11.33±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). |
| Target | TGFβR1(ALK5); Alk5 |
1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- - Reference
| Reference Show more | 1: Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P,Mennerich D, Schnapp A, Park JE. Design, synthesis, and evaluation of indolinonesas inhibitors of the transforming growth factor β receptor I (TGFβRI). J MedChem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a. PubMed PMID: 20919678. |
1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.022 ml | 10.109 ml | 20.217 ml |
| 5 mM | 0.404 ml | 2.022 ml | 4.043 ml |
| 10 mM | 0.202 ml | 1.011 ml | 2.022 ml |
| 5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
Last Update：2024-01-02 23:10:35
1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- - Cell Experiment
The high-content cytotoxicity assay (kit I) was performed according to the manufacturer’s instructions. HaCaT cells were cultured overnight in black 96-well plates, incubated for 24 h with each compound at different concentrations, and stained with cytotoxicity cocktail. Cells were fixed, washed, and scanned on the Cellomics ArrayScan II platform. Images were analyzed with the Cell Health image analysis algorithm. Cytotoxicity indices were calculated for each of the four parameters (cellular membrane integrity, nuclear fragmentation and density, and lysosomal mass) to indicate the percentage of cells outside of the normal range which was defined using a vehicle-treated reference cell population.
Last Update：2023-08-16 21:32:38
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)-
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